Phosphonomethyl analogues of phosphate ester glycolytic intermediates
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چکیده
منابع مشابه
Phosphonomethyl Analogues of Phosphate Ester Glycolytic Intermediates By HENRY
Analogues of dihydroxyacetone phosphate and of 3-phosphoglycerate were made in which the phosphate group, -O-PO3H2, is replaced by the phosphonomethyl group, -CH2-PO3H2. The analogue of dihydroxyacetone phosphate is a substrate for aldolase and glycerol 1-phosphate dehydrogenase (Stribling, 1974), but not for triose phosphate isomerase. The analogue of 3-phosphoglycerate oxidizes NADH under the...
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The enzymic synthesis of the 1-phosphonomethyl isostere of fructose 1,6-diphosphate in which the 1-phosphate (-OPO(3)H(2)) is replaced by the phosphonomethyl group (-CH(2)PO(3)H(2)) is described. The kinetic properties of this fructose diphosphate isostere and of 4-hydroxy-3-oxobutylphosphonic acid, an isostere of dihydroxyacetone phosphate, with aldolase (EC 4.1.2.13), fructose diphosphatase (...
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The human red blood cell is readily available in a wide range of quantities and can be processed to a highly purified single cell suspension. It normally converts glucose almost quantitatively to lactic acid, and this conversion appears to be a predominant fraction of the total metabolic activity (1). Because of these characteristics the human red cell provides a convenient material for the stu...
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This review presents a brief account of the chemistry and mechanistic aspects of aryl H-phosphonates, and selected applications of this class of compounds as intermediates in the synthesis of a wide range of biologically important analogues of nucleoside phosphates, and oligonucleotides, in which the phosphate moieties are replaced by other structurally related groups. The aryl nucleoside H-pho...
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Rat diaphragm was incubated with [WI-glucose or [‘“Clpyruvate; a number of the phosphorylated glycolytic intermediates were then isolated and their specific activities determined. Following incubation with either substrate, the specific activities of fructose 6-phosphate, fructose 1,6-diphosphate, and phosphoenolpyruvate were very close to that of the substrate. The specific activities of gluco...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1974
ISSN: 0264-6021
DOI: 10.1042/bj1410715